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Larvicidal activity of 1,3,4- oxadiazole analogues and their Molecular Docking Studies
参考中译:1，3，4-恶二唑类似物的杀幼虫活性及其分子对接研究


        

文集名：1st International Conference on Smart Technologies and Systems for Next Generation Computing (ICSTSN 2022)
作者：K. Santhanalakshmi（Chemistry, IFET college of Engineering (Autonomous)）
K. Margandan（Chemistry, IFET college of Engineering (Autonomous)）
Gomathi Thandapani（Chemistry, D.K.M. College for Women (Autonomous)）
N. Neelakandeswari（Chemistry, Nallamuthu Gounder Mahalingam College）
会议名：1st International Conference on Smart Technologies and Systems for Next Generation Computing (ICSTSN 2022)
会议日期：25-26 March 2022
会议地点：Villupuram, India
出版年：2022
页码：365-370
总页数：6
馆藏号：343709
分类号：TP3-53/I59/(1st)
关键词：2-(5-bromo-2-(trifluoromethoxy)phenyl)-5-aryl-1；3；4-oxadiazole；Ultrasonic radiation；Larvicidal activity；Urban mosquitoes；Zone of inhibition
参考中译：2-(5-bromo-2-(trifluoromethoxy)phenyl)-5-aryl-1；3；4-恶二唑；超声波辐射；杀幼虫活性；城市蚊虫；抑制区
语种：eng
文摘：A new series of 2-(5-bromo-2-(trifluoromethoxy)phenyl)-5-aryl-1,3,4-oxadiazole 4a-4h compounds (aryl = C_6H_5, p-ClC_6H_4, p-NO_2C_6H_4, C_5H_4N, p-OCH_3C_6H_4, p-BrC_6H_4, p-OHC_6H_4, p-CH_3OC_6H_4) were synthesiazed by recting acid hydrazide with 5-bromo-2-(trifluoromethoxy) benzoic acid in POCl_3. The new synthetic approach concluded with good results. The structure of synthesized Oxadiazole derivatives have been confirmed by Fourier transform infrared spectroscopy, Proton nuclear magnetic resonance and Carbon-13 NMR spectroscopy. The intention of this study to evaluate strong larvacidal activity of synthesized compounds towards Culex quinquefasciatus mosquitoes. The outcomes indicated that larvacidal activity of the synthesized compounds due to the existence of groups in the phenyl ring present of oxadiazole derivatives.
参考中译：合成了一系列新的2-(5-bromo-2-(trifluoromethoxy)phenyl)-5-aryl-1，3，4-oxadiazole 4a-4h化合物(芳基=C_6H_5，p-ClC_6H_4，p-NO_2C_6H_4，C_5H_4N，p-OCH_3C_6H_4，p-BrC_6H_4，p-OHC_6H_4，用5-溴-2-(三氟甲氧基)苯甲酸与酸肼在三氯氧磷中反应合成了对甲基乙酸乙酯。所合成的恶二唑衍生物的结构经傅立叶变换红外光谱、质子核磁共振和碳13核磁共振谱确证。本研究旨在评价合成的化合物对致倦库蚊具有较强的杀蚊活性。结果表明，由于苯环上基团的存在，所合成的化合物的杀幼虫活性存在于恶二唑衍生物中。

注：参考中译为机器自动翻译，仅供参考。



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